Emeramide® has been found experimentally not to reduce normal essential minerals in the animal and human studies we’ve conducted to date. In some animal studies where they were fed more than 100 times the amount recommended zinc may have been somewhat lowered until the drug was stopped. Depletion of essential metals has not been seen in humans or animals taking the lower amounts needed to effectively treat heavy metal toxicity. The normal human dose is 3 to 4 mg/kg.