Emeramide: Features of an investigational chelator
EmeraMed Ltd is a biotechnology company developing Emeramide (N,N′-bis(2-mercaptoethyl)isophthalamide), a lipophilic compound that has been studied for its ability to cross the blood-brain barrier and reach the inside of cells. Emeramide is an investigational compound and has not been approved by the FDA for any use. In preclinical studies, researchers reported that Emeramide can chelate (bind) mercury.
Important notice
Emeramide (NBMI) is an investigational new drug. Not approved by the U.S. FDA for any use. This material is for scientific information only and does not constitute evidence of safety or efficacy.
Emeramide: Development History
Emeramide was first introduced in 2008 as OSR#1®. Approximately 2.5 million doses of the compound were distributed. Clinical studies have been conducted, including Phase 1 and Phase 2 trials.
Properties
Emeramide is lipophilic, meaning it is soluble in fatty tissues. Laboratory experiments have examined the formation of complexes with certain metals. The resulting complexes have been studied for characteristics such as solubility in fat, water, acid, or base, as well as thermal stability.
Emeramide: Safety Observations
In safety studies in multiple animal species, researchers reported no evidence of toxicity at the doses tested. In human studies involving administration for up to 30 days at 300 mg per day and 10 days at 600 mg per day, no adverse events were reported and no depletion of essential minerals was observed in the published data. Additional studies in animals given the preformed metal complex reported no evidence of harm. These findings do not establish that Emeramide is safe or effective for any use.
Legal Disclaimer
This page provides general information about the chemical composition and development history of Emeramide. Emeramide has not been approved by the U.S. Food and Drug Administration (FDA) for any purpose. The information on this website has not been evaluated by the FDA. Emeramide is an investigational compound. It is not available for general use. Any potential use of this compound must be conducted in full compliance with all applicable federal, state, and local laws and regulations.